Cluster
Busters

The Case of Dr. Wanda B. Better

Welcome to Ohio!
"The Buckeye State"

Population:
11,256,654
(7th in US)

Area:
40,953 sq. mi.

State flower:
Scarlet Carnation

State Bird:
Cardinal


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squigbullet.gif (861 bytes) SOMEWHERE- TOWN, Ohio
   
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© 1996-2002, The University of Arizona
 
Page Content:  Marti Lindsey

Ohio State Health Department

 
Case-control study results for
pulmonary hemosiderosis

   
     

Table 1. Matching for Case and Control Groups
Table 2. Interview Survey Results for Exposure Assessment

Table 3. Comparison Blood & Urine Test Results
Table 4. Environmental Assessment Results within the Homes

 


Table 1.
Matching for Case and Control Groups

 

Case Infants

Control Infants

Infant Ages

Matched w/in 2 weeks of birth

Mean Maternal Age

21.2 years

24.3 years

Mean Maternal Education

11.4 years

11.5 years

Receives Medicaid Assistance

80%

83%

Average Age of Home

76 years

75 years

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Table 2.
Interview Survey Results for Exposure Assessment

*Note: The health department was only able to interview 10 of the case families

Type of Exposure

Case Infants
n = 10

Control Infants
n = 20

Yes

No

Yes

No

Tobacco smoke

9

1

11

9

Cocaine during pregnancy

1

9

1

19

Breast feeding

0

10

7

13

Lived in same dwelling since conception to time of illness

10

0

18

2

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Table 3.
Comparison Blood & Urine Test Results
(significantly different at the P<0.05 level)

 

Case Infants
(Mean results)

Control Infants
(Mean results)

Hematocrit

24.0%

32.6%

Hemoglobin

8.3 g.dL

11.2 g/dL

Red Blood Cell Count

3.5 million/mm3

4.2 million/mm3

Hemolysis

Yes

No

Milk-specific IgE

Negative

Higher levels

Glucose-6-phosphate dehydrogenase

Negative

Negative

Sickle Cell

Negative

One positive

Pesticides (organophosphate, carbamate, pyrethrins)

Below detection limits

Below detection limits

Volatile Organic Compounds (VOCs)

Below detection limits

Below detection limits

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Table 4.
Environmental Assessment Results within the Homes

 
Table 4a. Water damage
Table 4b. Indoor Air Quality - Pesticides
Table 4c. Indoor Air Quality - Volatile Organic Compounds - Fungi - Stachybotrys atra - Air Samples
Table 4d. Indoor Air Quality - Volatile Organic Compounds - Fungi - Stachybotrys atra - Surface Samples
Table 4e. Indoor Air Quality - Volatile Organic Compounds - Fungi - Cladosporium - Air Samples
Table 4f. Indoor Air Quality - Volatile Organic Compounds - Fungi - Cladosporium - Surface Samples 

Table 4a.
Environmental Assessment Results within the Homes
Water Damage
Test/Inspection
Case Infants
n = 10
Control Infants
n = 20
Water damage
(visual inspection)
10
5

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Table 4b.
Environmental Assessment Results within the Homes

Indoor Air Quality - Pesticides
(in patient’s bedroom or room where majority of patient’s time is spent)
Test/Inspection  
Case Infants
n = 10
Control Infants
n = 20
Pesticides (organo- phosphate, carbamate, pyrethrins) trace amounts* of chloro-pyrifos, diazinin, & other carbamate or pyrethrin compounds found in 3 homes
(cases 14, 5, 9)
trace amounts* of chloropyrifos, diazinin, & other carbamate or pyrethrin compounds found in 6 homes
* trace amounts are slightly above detection limits but are
below concentrations known to cause health effects.

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Table 4c.
Environmental Assessment Results within the Homes

Indoor Air Quality - Volatile Organic Compounds - Fungi - Stachybotrys atra - Air Samples
Test/
Inspection
 
Case Infants
n = 10
Control Infants
n = 20
Fungi
Air Samples
Stachybotrys atra Units: Colony Forming Units (CFU)/m3
Below detection limits Below detection limits
  Case 1: 33 Control 1: 0 Control 11: 30
Case 2: 46 Control 2: 0 Control 12: 0
Case 3: 43 Control 3: 0 Control 13: 0
Case 4: 57 Control 4: 23 Control 14: 0
Case 5: 36 Control 5: 0 Control 15: 0
Case 6: 45 Control 6: 0 Control 16: 0
Case 7: 49 Control 7: 0 Control 17: 0
Case 8: 32 Control 8: 0 Control 18: 0
Case 9: 0 Control 9: 0 Control 19: 0
Case 10: 49 Control 10: 36 Control 20: 0

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Table 4d.
Environmental Assessment Results within the Homes

Indoor Air Quality - Volatile Organic Compounds - Fungi - Stachybotrys atra - Surface Samples
Test/
Inspection
Case Infants
n = 10
Control Infants
n = 20
Fungi -
Surface Samples
Stachybotrys atra Units: Colony Forming Units (CFU)/m3
Below detection limits Below detection limits
  Case 1: 1.6 x 107 Control 1: 0

Control 11: 3.2 x 104

Case 2: 1.7 x 107 Control 2: 0 Control 12: 0
Case 3: 2.1 x 107 Control 3: 0 Control 13: 0
Case 4: 2.3 x 107 Control 4: 3.1 x 104 Control 14: 0
Case 5: 1.7 x 107 Control 5: 0 Control 15: 0
Case 6: 2.0 x 107 Control 6: 0 Control 16: 0
Case 7: 2.2 x 107 Control 7: 0 Control 17: 0
Case 8: 1.8 x 107 Control 8: 3.0 x 104 Control 18: 2.5 x 104
Case 9: 0 Control 9: 0 Control 19: 0
Case 10: 2.5 x 107 Control 10: 2.4 x 104 Control 20: 0

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Table 4e.
Environmental Assessment Results within the Homes

Indoor Air Quality - Volatile Organic Compounds - Fungi - Cladosporium -
Air Samples
Test/
Inspection
 
Case Infants
n = 10
Control Infants
n = 20
Fungi
Air Samples
Cladosporium Units: Colony Forming Units (CFU)/m3
Below detection limits Below detection limits
  Case 1: 1339 Control 1: 0 Control 11: 88
Case 2: 1400 Control 2: 0 Control 12: 0
Case 3: 1555 Control 3: 103 Control 13: 0
Case 4: 1222 Control 4: 66 Control 14: 0
Case 5: 1756 Control 5: 0 Control 15: 93
Case 6: 1544 Control 6: 0 Control 16: 0
Case 7: 122 Control 7: 0 Control 17: 0
Case 8: 1652 Control 8: 0 Control 18: 0
Case 9: 1199 Control 9: 195 Control 19: 0
Case 10: 1433 Control 10: 0 Control 20: 0

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Table 4f.
Environmental Assessment Results within the Homes

Indoor Air Quality - Volatile Organic Compounds - Fungi - Cladosporium -
Surface Samples
Test/
Inspection
 
Case Infants
n = 10
Control Infants
n = 20
Fungi -
Surface Samples Cladosporium
Units: Colony Forming Units (CFU)/m3
Below detection limits Below detection limits
  Case 1: 1.0 x 106 Control 1: 1.5 x 106 Control 11: 1.0 x 106
Case 2: 1.7 x 106 Control 2: 3.1 x 106 Control 12: 3.9 x 106
Case 3: 2.1 x 106 Control 3: 1.1 x 106 Control 13: 1.0 x 107
Case 4: 5.0 x 106 Control 4: 5.2 x 106 Control 14: 4.4 x 106
Case 5: 1.7 x 106 Control 5: 3.6 x 106 Control 15: 2.7 x 106
Case 6: 2.0 x 106 Control 6: 3.9 x 106 Control 16: 5.4 x 106
Case 7: 2.8 x 106 Control 7: 4.1 x 106 Control 17: 2.0 x 106
Case 8: 1.8 x 106 Control 8: 3.3 x 106 Control 18: 7.0 x 106
Case 9: 5.0 x 105 Control 9: 3.5 x 106 Control 19: 3.8 x 106
Case 10: 2.5 x 106 Control 10: 3.6 x 106 Control 20: 3.7 x 106

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coep-info@pharmacy.arizona.edu
Stefani Hines, Director: 520-626-3692
Marti Lindsey, Asst. Specialist: 520-626-7659
520-626-4468(FAX)

mailing address:
Southwest Environmental Health Sciences Center
University of Arizona College of Pharmacy, Room 244
PO Box 210207, Tucson, AZ, USA  85721-0207